Mixon sits out with a foot/ankle injury on the non-football injury list and has shown no practice since mid-July, with unclear return timing that keeps fantasy managers cautious about his 2025 value.

Mixon is listed under Texans' injuries; status unclear. His inclusion signals a potential backfield role shift or a concern for Houston’s run game balance, with Tank Dell and Christian Kirk providing receiving threats.

Mixon is on the Texans’ radar as a season-long question due to a foot injury, placed on NFI-reserve with a four-game minimum sidelined window and no clear timetable. The fantasy fallout centers on Houston’s backfield pivoting to Nick Chubb as the primary option, with Pierce and Marks as immediate depth. Managers should consider IR stash or active replacement in redraft leagues, given the ambiguity around his return.

Mixon is on IR and out of Week 1, testing Houston’s depth at back. The early-season workload shifts to Chubb and Marks, with Dameon Pierce contributing as depth in the backfield. Mixon’s absence sets a cautionary tone for Texans’ fantasy projections until he’s cleared.

Mixon’s injury opens the door for Chubb’s elevated workload, with Mixon's uncertain status creating a dynamic risk-reward element for Texans' backfield planning.